DNA mismatch correction.

PERSPECTIVES ANDUMMARY .............................................................. 435 BIOLOGY OFMISMATCH ORRECTION ................................................... 437 Evidence for Mismatch Processing in Vivo .................................................. 437 Postreplication Repair of Biosynthetic Errors ............................................... 438 dam-Independent Mismatch Correction in E. coli .......................................... 442 Mismatch Specificity .............................................................................. 444 STRUCTURES OF BASE PAIR MISMATCHES .............................................. 445 Extent of DNA Helix Disruption by Noncomplementary Bases: Melting Behavior and Single-Strand Nuclease Sensitivity .............................. 446 G-T and A-C Transition Mismatches ......................................................... 448 Purine-Purine and Pyrimidine-Pyrimidine Transversion Mismatches ................... 454 Insertion~Oeletion Mispairs ..................................................................... 456 Implications for Mismatch Recognition ....................................................... 457 MISMATCH CORRECTION IN VITRO ........................................................ 458 Requirements for Methyl-Directed Mismatch Correction in Vitro ....................... 458 Proteins Required for dam-Directed Mismatch Repair .................................... 459 Repair DNA Synthesis Associated with Methyl-Directed Mismatch Correction ....... 461 Models for Methyl-Directed Mismatch Correction ......................................... 461